Page 51 - Risk quantification and modification in older patients with colorectal cancer
P. 51

                                 Analysis (including? time interval between predictor and outcome was reasonable, part of eligibility)
H High risk if
Risk of bias
L Low risk if
M Moderate risk if H High risk if
Applicability concern L Low if
M Moderate if H High if
Applicability concern L Low risk if
M Moderate if
H High if Applicability concern L Low if
M Moderate if H High if
- loss-to-follow-up was higher than 20% and/or
- there were important differences on key characteristics
between included participants and those who were lost- to-follow-up or missing or
-loss-to-follow-up was not described
- relevant aspects of analysis were described allowing to judge the quality of the analysis to be adequate
- # outcome events per candidate predictor reasonable - missing data handled appropriately or no differences - predictors included independent of p-value
- overfitting and optimism accounted for
- weights assigned according to the regression coefficient - calibration and discrimination assessed
- recalibrated or described that it was not needed
- relevant aspects of analysis were described allowing to judge the quality of the analysis to be adequate and part or none of the model evaluation items were reported
not satisfying any of the aspects under low risk of bias
Items to be considered for applicability concern
Truly representative of an average elderly patient with colorectal cancer
And > 30% older patients (65) were included
Somewhat representative of the average older patient with colorectal cancer
Not representative of the average older patient with colorectal cancer OR
no clear definition
- Predictors are available for older patients with colorectal cancer and
- All Predictors are preoperatively assessed
One of the above criteria was not met Both criteria were not met
- Outcome applicable to older patients with colorectal cancer
- Outcomes discussed could change a treatment decision
If one of the above criteria was not met None of the criteria was met
Risk prediction models for CRC patients
       Applicability concert
Participant selection
Predictor
Outcome
            49
2
 

























































   49   50   51   52   53