Page 32 - Risk quantification and modification in older patients with colorectal cancer

Chapter 2
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Table 1 Characteristics of the 25
Selected Prediction Modelling Studies
UK
Author
Cohort years
Model “name”
Outcomes
type of surgery
Single or multicentre or /data source
Pro/retro- spective
Tu- mour stages
No. of pa- tients
Mean age (range)
Patients > 65a of >70b
Tekkis et al. 10
1993-2001 1976-2002 2002 2005-2007
CR-POSSUM CCF-CRM AFC Index ACS-NSQIP
In-hospital mortality
CR surgery (37.2% CRC)
Multicentre (n=15)
Pro Pro Pro Pro
I-IV I-IV NR I-IV
6883 NR
37%b 50%a 46%a NR
Fazio et al. 11
30-day mortality
CRC surgery
Single Centre
5053 Median 66 (18-98)
USA
Slim et al. 12
In-hospital mortality
CR surgery (CRC 70%)
Multicentre (n=81)
1421 NR
France
Cohen et al. 13
1. 30-day mortality 2. 30-day overall and severe morbidity
CR surgery (49% CRC)
ACS-NSQIP database
28863/ Mean 61.8 3037 (SD 15.9)
USA
(V)
Farooq et al. 14
2001-2007 2005-2006 1997-2007 2008-2010 2005-2007
CR-BHOM CLS Revised ACPGBI COLA-score Elderly ACS-
1. 30-day mortality 2. Major morbidity
CRC surgery
Single Centre
Pro Meta-analysis Pro
Pro
Pro
NR NR I-III NA I-IV
704 Median 74 (24-98)
NR
UK
Dekker et al. 15
Anastomotic Leakage 30-day mortality
Left-sided CRC
Single Centre
121 Median 66 (25-93)
NR 67%a NR 35%b
The Netherlands
Richards et al. 16
Curative CRC surgery
Single Centre
423 NR
UK
Gervaz et al. 17
1. SSI – superficial 2. SSI - deep
CR surgery
Multicentre (n=24)
543 NR
Switzerland
Kiran et al. 18
30-day mortality
CR surgery (% CRC NR)
ACS-NSQIP database
235407 Non-elderly 52.8
USA
NSQIP
-
IRCS Anastomoticleak.
Elderly (70+)78.4
Pasic et al. 19
2009-2011 1990-2011 2011-2012
Anastomotic leakage In-hospital mortality Anastomotic leakage
CR surgery CRC surgery CRC surgery
Single Centre Single Centre
Retro Pro Pro
NR 119
Mean 62 (33-87)
NR 49%b
Bosnia and Herzegovina
Van der Sluis et al. 20
I-IV I-IV
2856 NR
The Netherlands
Frasson et al. 21
Multicentre (n=52)
3193 Median NR (63-79)
Spain
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