Page 165 - Risk quantification and modification in older patients with colorectal cancer
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                                Table 2A Baseline QLQ-C30 scores with stratification based on functional dependency
Oncogeriatric care and Health Related Quality of Life
Baseline HRQoL
Tables 2A and 2B show the baseline and uncorrected differences in HRQoL scores between functionally independent and dependent patients. Functionally dependent patients reported lower physical functioning, role functioning, global health and more symptoms such as fatigue and pain (all p<0.001). The HRQoL summary score was, on average, 17 points lower for functionally dependent patients compared to functionally independent patients (68.9 versus 86.4, p<0.001). The clinical relevance of the majority these differences in baseline scores can be classified as medium to large.
     QLQ-C30
Physical Functioning Role Functioning Emotional Functioning Cognitive Functioning Fatigue
Pain
Global Health
summary score
Independent Dependent n=80 n=26 mean (SD) mean (SD) 81.6 (28) 62.4 (28) 80.0 (37) 55.8 (37) 84.8 (16) 78.1 (16) 89.6 (18) 84.7 (18) 28.5 (35) 51.3 (35) 14.2 (35) 34.0 (35) 76.5 (20) 61.5 (20)
86.4 (12) 68.9 (18)
Relevancea
p-value
<0.001 <0.001 0.1 0.2 <0.001 0.001 <0.001
<0.001
medium medium none none large large large
large
 Numbers as mean values with corresponding (SD). aInterpretation of clinical relevance based on Cocks et al.33
Table 2B Baseline QLQ-CR38 scores with stratification based on functional dependency
     QLQ-CR38
Future Perspective Gastointestinal Problems Weight Loss
Independent Dependent n=80 n=26 mean (SD) mean (SD) 70.8 (23) 60.3 (28) 16.5 (14) 26.7 (16) 18.6 (24) 33.3 (35)
Relevanceb
p-value
0.06 0.003 0.02
none relevant relevant
 Numbers as mean values with corresponding (SD). bInterpretation of clinical relevance based on Norman’s rule of thumb35
HRQoL over time for dependent and independent patients
The observed mean scores of the HRQoL domains over time for functionally dependent and independent patients are depicted in figures 2A and 2B.
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