Page 86 - The autoimmune hypothesis of narcolepsy and its unexplored clinical features M.S. Schinkelshoek
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Chapter 5
et al., 2009), while another study showed a 5.2kg weight loss after 3 months of SXB treatment (Donjacour et al., 2014). This has not yet been confirmed and long-term follow-up data is not available. We here provide longitudinal BMI data of NT1 patients after starting treatment with SXB, compared to patients in whom treatment with modafinil was initiated. Our hypothesis is that BMI decreases upon introduction of SXB, while use of modafinil will not affect BMI.
Methods
Subjects
Medical records of consecutive individuals diagnosed with NT1 attending the outpatient clinic of the Sleep-Wake Center Stichting Epilepsie Instellingen Nederland (SEIN) and the outpatient clinic of the Leiden University Medical Centre between 2009 and 2017 were reviewed retrospectively. All individuals included (n=81) fulfilled the criteria for NT1 as formulated in the third edition of the International Classification of Sleep Disorders (ICSD-3, 2014). Only those who initiated treatment with either SXB or modafinil and used it for at least three months were included. Those who had already used one of the medications were excluded. Patients were also excluded if there were no measurements recorded, if they suffered from another disorder that is associated with obesity (e.g. hypothyroid disease) or if they were under the age of 18 years. The follow up period ended prematurely if the SXB or modafinil treatment was discontinued, or when additional medication was started. Relevant co- medication use (antidepressants, methylphenidate, dexamphetamine) was extracted from the records. The decision to prescribe either modafinil or SXB was a clinical decision based on the presence and severity of the various NT1 symptoms. Weight at treatment start did not play a role in this decision.
Study design
This is a retrospective follow-up study in which the above described individuals were followed up to July 31st 2017. Weight, length and medication, assessed at the beginning of each visit to the outpatient clinic were extracted from the records. BMI was calculated by dividing the weight (kg) by the squared length (m2) for each visit.



























































































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