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Figure 4 β5i proteasome subunit immunoreactivity in control, FCD type IIa, FCD type IIb and TSC. Panels A and B: control cortex (A) and with matter (B) with weak β5i expression. Panel C (FCD IIa) shows expression within the dysplastic region with positive dysmorphic neurons (arrows and insert, nuclear expression) and glial cells (arrow-heads). Panels D-E (FCD IIb) show several β5i positive cells within cortex (D) and white matter (E), including dysmorphic neurons (arrow in D), glial cells (arrow-heads D and E; insert in D) and balloon cells (arrows in E; insert : co-localization with pS6). Panels F-G (TSC-tuber): strong β5i subunit expression is observed within the tuber in dysmorphic neurons (F: arrows and inserts a and b; b, co-localization with the neuronal marker NeuN; c, co-localization with pS6), glial cells (arrows in G; insert in G, co-localization with GFAP) and in giant cells (arrows in H; insert: co-localization with HLA-I). The inserts within panels show imagines of the different cells types at higher magnification in separate specimens. Scale bar in H: A-C: 80 μm; D-H: 40 μm.
































































































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