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Supplementary information
 Supplementary Figure 1 Color segmentation recipe. For extraction of the total amount of DAB staining the following filters were used to calculate the accurate amount.
Supplementary Figure 2 Cluster analysis. A. Hierarchical clustering (Ward’s method) on the parameters: SMI32 (amount of dysmorphic neurons), vimentin (amount of giant cells) and pS6- Ser235/236 (mTOR activation) identified three different tuber patterns. B. 3D dot plot of the identified patterns within their clustering matrix.
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