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The research described in this thesis was performed at the department of (Neuro) Pathology of the Amsterdam UMC, University of Amsterdam and was funded by the European Union’s Seventh Framework Programme (FP7/2007-2013) under the grant agreement no. 602391 (EPISTOP).
The printing of this thesis was financially supported by the Graduate School and the department of Pathology of the Amsterdam UMC, University of Amsterdam, and the Stichting Tubereuze Sclerosis Nederland (STSN).
Cover design & lay-out by J. van Scheppingen. Printed by GVO drukkers & vormgevers B.V.
































































































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