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type A tuber was correlated with a lower drug load at the time of surgery and a shorter duration of active epilepsy, and none of the included patients classified as having a type A tuber underwent hemispherotomy, type A seems a milder phenotype. In contrast, acti- vation of inflammatory pathways seen in type B tubers could be the underlying mech- anism that leads to a more severe epileptic pathology. For future studies, it would be interesting to compare the histological patterns of tubers that are considered causative for seizure onset to non-seizure onset tubers, the latter one often also resected during epilepsy surgery due to proximity of the tubers 8.
In addition to gene expression, we also investigated DNA methylation profiles of TSC cortical tubers. DNA methylation is an epigenetic way of regulation of gene expres-
DISCUSSION
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