Page 99 - The clinical aspects and management of chronic migraine Judith Anne Pijpers
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Figure 2. COHORT flow diagram
Patient flow including the double blind randimized phase (weeks 0 – 12) and regular care follow up (weeks 24, 36, 48). Not all numbers add up, as some patients decided to continue participation after one missed visit.
Successful withdrawal, defined as ≤ 2 days/month escape use of acute headache medication in the first 12 weeks of the study, was achieved in 82 (93%) of patients in the maximal intervention group, and 75 (86%) of those who received minimal intervention. The odds ratio for success was 2.44 (95%CI: 0.83 to 7.23, p=0.107) for maximal versus minimal intervention. The days with use of acute headache medication in this period was low in both groups, with no difference between groups (mean difference -0.76, 95%CI: -0.22 to 1.74, p=0.128) (Figure 3).
Patients in the maximal intervention group did have fewer monthly days with use of acute headache medication after 24 weeks (5.26 versus 7.49; mean difference: -2.23, 95%CI: -3.76 to -0.70, p=0.005) (Figure 3). The difference between the two groups disappeared over time (mean differences after 36 weeks: -0.77, 95%CI: -2.66 to 1.12, p=0.423 and after 48 weeks: -0.20, 95%CI: -1.90 to 1.49, p=0.812) (Figure 3).
Behavioural intervention: a double blind RCT
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