Page 130 - The clinical aspects and management of chronic migraine Judith Anne Pijpers
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Chapter 7
Furthermore, especially mechanical allodynia, as opposed to thermal allodynia, was related to outcome. The predictive value of cutaneous allodynia was limited to migraine-specific outcome, not to reduction in headache days in general. The study indicates the relevance of cutaneous allodynia as marker for central sensitization in chronic migraine and its predictive value for response to withdrawal therapy. As central sensitization, mediated by CGRP, is a key mechanism in migraine chronification, cutaneous allodynia may very well be an important predictor for treatment response in chronic migraine in general. Furthermore, the subtypes of cutaneous allodynia have never been studied in this context, and could enhance the predictive value for migraine-related outcomes and increase insight in the mechanisms of chronification in migraine.
































































































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