Page 109 - Advanced echocardiography in characterization and management of patients with secondary mitral regurgitation
P. 109
diameter and EROA. These findings demonstrate the complementary deleterious effects of a greater EROA (reflecting the severity of secondary MR) and an enlarged anteroposterior mitral annular diameter (reflecting long-standing volume overload). By reducing MR and having long-term favorable effects on LV remodeling (13,16), treatment of severe secondary MR with the MitraClip plus GDMT thus improves freedom from both death and HFH during long-term follow-up in selected patients with HF.
Central Illustration. Interactions between treatment arm and baseline mitral valve geometry and regurgitation severity for the 2-year composite endpoint of all-cause death or heart failure hospitalization (A), all-cause death alone (B) and heart failure hospitalization alone (C).
Panel A
107
Ch 5
