Page 77 - When surgery alone won’t cut it - Valerie Maureen Monpellier
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  BL (n=2130) Mean ±SD
     15M (n=1953) Mean ±SD
  56.9 18.7
    91.1 * 12.5
   42.6 21.3 48.3 26.3 60.0 31.6 62.0 24.1 71.3 22.4
           89.8 * 13.7 87.5 * 18.3 88.8 * 20.2 94.2 * 12.8 94.9 * 12.1
       IWQOL-lite
Total
physical function self-esteem sexual life
public distress work
24M (n=612) Mean ±SD 89.9 * 12.7 88.7 * 13.1 85.7 * 19.0 86.8 * 22.3 93.6 * 12.7 94.7 * 12.0
      *significant difference compared to baseline, p<0.001; †significant difference compared to 15-month follow-up, p≤0.001; ° significant difference compared to 15-month follow-up, p≤0.05
BL = baseline; 15M = 15-month follow-up; 24M = 24-month follow-up
Baseline BMI and HRQoL
A higher baseline BMI was significantly associated with a lower baseline PHS-score (R2=0.005, F(1,2131)=10.539, p<0.001). There was no significant association between baseline BMI and baseline MHS score. IWQOL-lite total score was also negatively associated with BMI (R2=0.037, F(1,2128)=82.420, p<0.001).
Follow-up weight and HRQoL
PHS-score was significantly negatively related to BMI at 15M (R2=0.013, F (1,2056) = 26.355, p<0.001) and 24M (R2=0.005, F (1,1019) = 5.403, p=0.020). MHS was only associated with BMI at 24M (R2=0.004, F (1,2056) = 3.956, p=0.047); this was also negative. IWQOL-lite total score was negatively associated with BMI at both 15M (R2=0.094, F (1,1935) = 201.653, p<0.001) and 24M (R2=0.139, F (1,601) = 97.412, p<0.001). A higher BMI was associated with a lower HRQoL in both RAND-36 subto- tals and the IWQOL-lite total score.
15M and 24M scores of PHS, MHS and IWQOL-lite total score were significantly associated with %TWL (p<0.001 in all). A higher %TWL was associated with a higher HRQoL in all RAND-36 subtotals and the IWQOL-lite total score.
Weight loss and change in HRQoL
At 15 months ΔHRQoL ranged from 0.07 to 0.57 for RAND-36 scores and for IWQOL- lite ΔHRQoL15 ranged from 0.23 to 0.47 for IWQOL-lite scores. Significant correlations with %TWL were found in the physical functioning scale (rs (2054) = 0.096, p<0.001) and general health perception scale (rs (2054) =0.091, p<0.001) of RAND-36. For the IWQOL-lite all scales had significant correlations; highest correlation was with self- esteem scale (rs (1931) = 0.147, p<0.001).
ΔHRQoL15 of PHS and IWQOL-lite total score were significantly associated with %TWL (p<0.001 in both). Also, after adjusting for baseline BMI, gender, age and comorbidities (diabetes mellitus, hypertension, obstructive sleep apnoea syndrome, hypercholesterolemia and osteoarthritis), %TWL was still significantly related to ΔHRQoL15 for PHS and IWQOL-lite total score (Table 3). For ΔHRQoL15 of MHS there was no significant association (p=0.213).
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