Page 102 - New epidemiological and PSMA-expression based paradigms in salivary gland tumors
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Chapter 6
head and neck that may lead to misinterpretation of tumor and normal tissues (Figure 1). Adequate knowledge of the normal anatomy and function of the salivary glands is relevant to further improve interpretation of the images. Assessment of salivary gland presence and function by PSMA PET/CT after treatment requires knowledge of quantitative physiological uptake patterns, which currently are not well understood.
This study aimed to describe the physiologic PSMA-ligand uptake distribution characteristics by evaluating tracer maximum standardized uptake values (SUVmax) in normal salivary glands, seromucous glands of the upper aerodigestive tract and lacrimal glands on PSMA PET/CT. In addition, this study aimed to identify potential clinical applications of PSMA PET/CT.
Figure 1: PSMA PET/CT of a patient with a history of cancer of the left parotid gland treated with surgery and radiotherapy, and prostate cancer treated with radiotherapy with current biochemical recurrence. An anterior projection of the body is shown (A), and transverse slices at the level of the neck (B) and upper thoracic outlet (C). The cytologically proven nodal metastasis from prostate cancer in the lower neck (NM) has equivalent uptake as the irradiated submandibular gland (SM) and several normal tissues in the neck (e.g., the glands in the supraglottic larynx). This may lead to confusion and misinterpretation when normal patterns are not adequately recognized.
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