Page 92 - Strategies for non-invasive managementof high-grade cervical intraepithelial neoplasia - prognostic biomarkers and immunotherapy Margot Maria Koeneman
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Chapter 4
Table 3. Results of 3q26 analysis and natural prognosis in 19 patients with high-grade CIN
Case
CIN grade
3q26 copy numbers
3c copy numbers
3q status
Regression (yes/no)
96 3 4 125 3 3,4 159 3 4 164 3 4
170 3 2-4
171 3 2-6
182 3 3,4 218 2 6-8 221 3 2-4 225 3 2-4 187 2 2-4 192 3 4 207 3 3 222 3 2-4 237 2 3,4 194 3 2 197 3 2 200 3 2 206 3 2
4 Gain No 3,4 Gain No 4 Gain No 4 Gain No 2-4 Gain No 2-6 Gain No 3,4 Gain No 3,4 Gain No 2-4 Gain No 2-4 Gain No 2-4 Gain Yes 4 Gain Yes 3 Gain Yes 2-4 Gain Yes 3,4 Gain Yes 2 No gain Yes 2 No gain Yes 2 No gain Yes 2 No gain Yes
Table 4. Test performance of 3q26 gain in the prediction of natural prognosis of high-grade CIN in 19 patients
10 5 15 044 10 9 19
Gain of 3q
No gain of 3q
Total
p=0.0325
Sensitivity:
Specificity:
Positive predictive value: Negative predictive value:
100% (95% CI 66-100%) 44% (95% CI 15-77%) 67% (95% CI 39-87%) 100% (95% CI 40-100%)
Persistence
Regression
Total
90
