Page 88 - Strategies for non-invasive managementof high-grade cervical intraepithelial neoplasia - prognostic biomarkers and immunotherapy Margot Maria Koeneman
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Chapter 4
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Study Baseline pathology
No. of cases
Specimen
Folow-up Follow-up HPV Distinction No. of Cutoff term measure tested? polyploidy/ evaluated
Cases with gain
Disease outcome
Ravaioli, 2017 CIN 1-3, histological
8*
Paraffin- embedded biopsies
0m – 10y Colposcopy Yes with biopsy
No
Min 60 cells > 2 signals in > 10% of cells,
3/8 (38%)
Low grade CIN: Remission:
1/3 (33%) Persistence: 1/3 (33%) Progression: 1/3 (33%)
diagnosis
or conization
pragmatic
* only those patients were included that were not treated at baseline aCervical intraepithelial neoplasia
blow-grade squamous intraepithelial lesion
3/5 (60%) Progression: 1/5 (20%)
catypical squamous cells of undetermined significance
gain
cells
High-grade CIN: Regression:
1/5 (20%) Persistence:
