Page 210 - Strategies for non-invasive managementof high-grade cervical intraepithelial neoplasia - prognostic biomarkers and immunotherapy Margot Maria Koeneman

Chapter 11
extensive excision or recurrent CIN lesion, with the aim to prevent repeated cervical surgery including hysterectomy. The efficacy of imiquimod in recurrent CIN lesions is currently being studied in the TOPIC-2 trial, performed by our research colleagues from the Erasmus MC.
- Remaining knowledge gaps with regard to imiquimod treatment of high-grade CIN are cost-effectiveness and patient and physician satisfaction with imiquimod treatment. These issues could be addressed in future studies. Finally, long-term studies should reveal whether imiquimod indeed reduces long-term side effects of surgical treatment, with emphasis on premature birth after both treatment modalities.
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