Page 110 - Strategies for non-invasive managementof high-grade cervical intraepithelial neoplasia - prognostic biomarkers and immunotherapy Margot Maria Koeneman

Chapter 5
Conclusion
We developed and internally validated a prediction model for spontaneous regression of CIN 2 lesions in a Western population. Upon external validation of its discriminatory capacity and accuracy, the model could be used in clinical practice to counsel patients with a CIN 2 diagnosis. When there is a high predicted chance of disease regression, the model could be used to reassure the patient that observation is an appropriate treatment option. As such, the model could function as a tool for a more individualized approach to CIN 2 management, and its use could reduce unnecessary treatment of CIN 2 lesions and the associated complications.
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