Page 56 - 89Zr-Immuno-PET:Towards a Clinical Tool to Guide Antibody-based Therapy in Cancer
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                                Chapter 3
 Figure 3: Immuno-PET images with 89Zr-cMAb U36 of head and neck cancer patient 19, with a tumor on the right side of the soft palate and a lymph node metastasis at the left side of the neck (level III). Images were obtained 72 h postinjection. A, coronal image of primary tumor; B, coronal image of lymph node metastasis in the neck; C, sagittal image of primary tumor; D, sagittal image of lymph node metastasis in the neck.
Preoperative findings obtained with immuno-PET, palpation, CT/MRI, and for a subgroup of patients with FDG-PET were compared with the histopathologic findings. Sensitivity, specificity, and accuracy of the different diagnostic modalities for detection of lymph node metastases per level and per side in the whole group of patients, are shown in Tables 2 and 3. Respective sensitivities of immuno-PET, palpation and CT/MRI were 72%, 44% and 60% when evaluated per neck level, and 73%, 53%, and 73% when evaluated per neck side. Accuracy of immuno-PET, palpation, and CT/MRI for the whole group of patients was per level 93%, 88%, and 90%, and per side 76%, 72%, and 80%, respectively.
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