Page 181 - 89Zr-Immuno-PET:Towards a Clinical Tool to Guide Antibody-based Therapy in Cancer
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                                Towards 89Zr-immuno-PET to measure target engagement of antibodies
 Figure 1 Biodistribution of a 89Zr-labeled mAb: physiological components 9
Reversible non-specific uptake (A) due to antibody in the vascular tissue compartment and antibody entering the tissue interstitium through paracellular pores, and through endothelial cells mediated by the neonatal Fc-receptor, leaving the tissue by convective transport through lymph flow. Irreversible non- specific uptake (B) due to mAb degradation in the lysosome, followed by residualization of 89Zr. Specific uptake (C) due to target engagement (target binding and internalization of mAb-target antigen).
Adapted from Lobo 2004 (8) and Chen 2012 (10).
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