Page 139 - 89Zr-Immuno-PET:Towards a Clinical Tool to Guide Antibody-based Therapy in Cancer
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Interobserver reproducibility of 89Zr-immuno-PET
Knowledge on in-vivo drug delivery of mAb-based therapy (including antibody- drug conjugates, bispecific mAbs and immune checkpoint inhibitors) is crucial to understand and predict efficacy of treatment.
CONCLUSION
This study shows that interobserver reproducibility of tumor uptake quantification on 89Zr-immuno-PET was excellent for SUVmax and SUVpeak using a standardized manual procedure for tumor segmentation. Semi-automatic delineation was not robust due to limited tumor contrast.
ACKNOWLEDGEMENTS
We thank Emma Mulder (Department of Radiology & Nuclear Medicine, VU
University Medical Center, Amsterdam, the Netherlands) and Nikie Hoetjes 6 (Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands) for pilot project support and Maqsood Yaqub (Department of
Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands) for the PET analysis software.
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