Page 68 - Quantitative Imaging of Small Tumours with Positron Emission Tomography
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                                Table 3.1: Median relative differences (% with IQR) in IDIF AUC of PVC-images compared to uncorrected images. Entire curve Peak only (2.5 min) PVC in dynamic PET-CT   Image-derived -0.8 (-1.2 to 0.6) -0.7 (-1.2 to 0.6) -0.8 (-1.2 to 0.6) *p<0.05. PP= parent plasma 3 Table 3.2: Relative changes (%) in kinetic parameter estimates and simplified metrics after PVC.  LR LR+HYPRmoving LR+HYPRsingle PP calibrated -0.7 (-1.3 to -0.2)* Image-derived -2.0 (-3.4 to -0.9)* PP calibrated -1.8 (-3.7 to -0.9)* -0.6 (-1.1 to -0.1)* 0.0 (0.0 to 0.0) -2.2 (-3.2 to -0.5)* -0.9 (-1.2 to 0.7) -2.0 (-3.3 to -1.1)* 0.0 (-0.1 to 0.1)     Mean Median SD IQR LR 6.0-16.4 2.6-11.1 2.1-10.7 7.3-17.1 7.3-17.1 LR+HYPR 6.1-15.5 2.3-10.0 0.1-7.1 7.0-16.7 7.0-17.0 Min Max -15.2 25.1 -16.7 32.3 -21.9 34.6 3.3 28.4 3.3 28.3 -13.6 21.7 -14.9 25.1 -20.6 19.8 2.1 24.7 3.1 27.3 p-value <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001  VT 11.8 K1 6.6 BP 6.1 SUV 13.1 TBR 13.1 VT 10.8 K1 5.7 BP 3.7 SUV 12.6 TBR 12.8 13.2 7.1 6.8 7.5 6.0 8.8 13.2 6.1 13.2 6.1 11.7 6.1 4.3 6.9 4.4 6.4 12.9 5.8 12.9 6.0  Table 3.3: Correlation (Spearman, with 95% confidence intervals) between PVC-induced relative changes in kinetic parameter estimates and simplified metrics.  VT K1 BP 0.51* (0.30-0.68) 0.51* (0.30-0.68) 0.36* (0.11-0.56) 0.36* (0.12-0.57)  SUV 0.58* (0.38-0.73) TBR 0.58* (0.38-0.73) SUV 0.62* (0.43-0.75) TBR 0.62* (0.43-0.75) *p<0.01 LR 0.61* (0.42-0.75) 0.61* (0.42-0.75) LR+HYPR 0.47* (0.24-0.65) 0.48* (0.26-0.66)  Kinetic parameter estimates and simplified metrics Relative differences between uncorrected and PVC data for K1, VT, BPND, SUV, and TBR are presented in Table 3.2. Both LR and LR+HYPRmoving significantly (p<0.001) increased each parameter. Overall, LR provided larger changes in parameters than LR+HYPRmoving for both kinetic parameters and simplified 67     


































































































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