Page 107 - Tyrosine-Based Bioconjugations - Jorick Bruins
P. 107

Engineering of Tyrosine-Containing Peptide Loops Enables Non-terminal Protein Labeling
stability after installing peptide tags in the CH2 region.19 By further altering the peptide tag and installing it in a region prone to instabilities, the antibody degrades within weeks.
Figure 5. HPLC chromatograms overtime of (A) Tras-Y1 and (B) Tras-Y2.
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