Page 119 - Tyrosine-Based Bioconjugations - Jorick Bruins
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Summary and General Discussion
Figure 3. Protection of CDR-H3 tyrosine by anti-AT1413 antibody (AIA) to generate (A) [2]:2:2 trifunctional constructs and (B) [2]:1:1 trifunctional constructs.
Of more relevance is to consider potential fields of application of SPOCQ, such as the production of antibody-drug conjugates (ADCs), radiolabelled antibodies, and even trispecific antibodies. The latter trispecific antibodies were effectively generated in chapter 5, but not evaluated for biological activity yet. Specifically, we generated trifunctional variants of the antibody AT1413,
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