Page 34 - Coronary hemodynamics in acute myocardial infarction - Matthijs Bax
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Chapter 2
tailed Student t test for paired or unpaired data, as appropriate, or by one- way analysis of variance (ANOVA) for more than two independent groups of data. The categorical variables were compared by chi-square or Fisher exact test where appropriate. Changes in global and regional WMI were tested by ANOVA for repeated measures. A p value <0.05 was considered statistically significant. Regression lines were obtained by least squares regression method. After determining univariate predictors of recovery of LV function and ejection fraction, multivariate stepwise linear regression analysis was applied to univariate variables with a significance level lower than 0.15. Qualitative variables were coded as 1 when the property was present and as 0 when absent. Statistical analysis was performed with SPSS version 10.0.7 (SPSS Inc., Chicago, Illinois).
Results
Clinical events
One patient died of a hemorrhagic stroke three days after primary PCI, and one patient of end-stage kidney failure with progressive heart failure at 147 days’ follow-up. One patient underwent coronary artery bypass grafting at day 89. Eight patients underwent repeat PCI (4 patients showed target lesion restenosis, 1 acute stent closure at day 14, and 3 patients underwent non-LAD coronary artery repeat PCI). Six patients with significant restenosis at six months’ follow-up were excluded from the analysis because of possible influences on LV function recovery. Ten patients with an uncomplicated clinical course at follow-up refused a reangiography. The remaining 73 of the initial 100 patients constitute the study cohort and were analyzed in the present study.
Baseline characteristics
Baseline clinical characteristics are shown in Table 1. Angiographic, Doppler, and procedural characteristics are shown in Table 2. Mean age of the analyzed patients was 54 ± 12 years. Mean summated ST-segment elevation before PCI was 26.5 ± 14.8 mV and after the procedure 7.9 ± 6.1 mV resulting in 18.6 ± 12.2 mV absolute ST-segment resolution. The relative resolution was 70.2 ± 23.0%. Mean time between reperfusion and second ECG was 106 ± 30 min. Mean cTfc in the LAD coronary artery after PCI was 44 ± 21 and in the reference
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