Page 123 - Coronary hemodynamics in acute myocardial infarction - Matthijs Bax
P. 123
Table 2. Intracoronary Doppler flow and CMR measurements.
Doppler flow measurements
Heart rate (beats/min) Systolic BP (mmHg) Diastolic BP (mmHg) Infarct-related artery
Baseline APV (cm/s) Hyperemic APV (cm/s) CFR
BMRI (mmHg/cm per sec) HMRI (mmHg/cm per sec)
Reference vessel
Baseline APV (cm/s)
Hyperemic APV (cm/s) CFR
BMRI (mmHg/cm per sec) HMRI (mmHg/cm per sec)
Relative CFVR
CMR measurements
LVEF (%)
LVEDV index (ml/m2) LVESV index (ml/m2)) IS (% LV)
Baseline
73.2±10.9 111.9±22.1 68.2±8.7
23.3±9.9 44.7±15.4 2.0±0.5 4.1±1.5 1.9±0.6
19.3±7.0 50±14.9 2.7±0.6 4.8±1.6 1.7±0.5 0.76±0.18
Baseline
Follow-up
64.3±11.6 121.7±20.8 70.5±10
17.2±9.1 51.7±19.5 3.2±0.8 6.0±2.3 1.8±0.6
17.1±6.1 54.7±17.6 3.3±0.7 5.6±1.9 1.6±0.5 0.99±0.24
Follow-up
Change
-8.9±10.2 9.8±19.2 2.3±11.5
-6.1±7.9 7±18.6 1.2±0.8 2.0±2.0 -0.2±0.7
-2.2±7.2 4.7±20.7 0.6±0.6 0.9±2.1 -0.1±0.5 0.2±0.3
Change
3.3±6.2 6.2±12.3 0.6±10.9 -5.0±3.7
p-value
<0.001 <0.001 0.12
<0.001 0.005 <0.001 <0.001 0.08
<0.001 0.08 <0.001 0.002 0.10 <0.001
p-value
<0.001 <0.001 0.68 <0.001
Recovery of microvascular dysfunction following STEMI
46.2±8.7 22.3±9.8 14.1±6.7
42.9±8.7
96.2±14.4 102.3±20.7 55.4±13.5 56.0±18.1
For the current analysis, all patient who had intracoronary flow measurements at both baseline and 7 follow-up were included (N=61).
APV: average peak velocity; BMRI: baseline microvascular resistance index; BP: blood pressure; CFR:
coronary flow reserve; CMR: cardiac magnetic resonance; HMRI: hyperemic microvascular resistance
index; IS: infarct size; LVEDV: left ventricular end-diastolic volume; LVEF: left ventricular ejection fraction; LVESV: left ventricular end-systolic volume
CFR in the subacute phase was associated with LVEF at four months (β=4.66, SE=2.10; p=0.03) and at two-year follow-up (β=5.84, SE=2.45; p=0.02) and inversely associated with LVEDV and LVESV index at four months and two years (Table 3). Additionally, CFR in the subacute phase was associated with the changes in LVEDV. HMRI in the subacute phase was not associated with LVF. In a multivariate regression model, CFR was not associated with LVEF at two years (Table 4).
121