Page 54 - Helicobacter pylori and Gastric Cancer: From Tumor microenvironment to Immunotherapy
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                                Chapter 2
Chapter 2
 68. Chen, J.K., et al., Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev, 2002. 16(21): p. 2743-8.
69. Ecke, I., et al., Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth. Mol Carcinog, 2008. 47(5): p. 361-72.
70. Warzecha, J., et al., Effect of the Hedgehog-inhibitor cyclopamine on mice with osteosarcoma pulmonary metastases. Int J Mol Med, 2012. 29(3): p. 423-7.
71. Pan, S., et al., Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med Chem Lett, 2010. 1(3): p. 130-4.
72. Lauth, M., et al., Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A, 2007. 104(20): p. 8455-60.
73. Hyman, J.M., et al., Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci U S A, 2009. 106(33): p. 14132-7.
74. Maun, H.R., et al., Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site. J Biol Chem, 2010. 285(34): p. 26570-80.
75. Stanton, B.Z., et al., A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol, 2009. 5(3): p. 154-6.
76. Goetz, J.A., et al., A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form. J Biol Chem, 2006. 281(7): p. 4087-93.
77. Petrova, E., et al., Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat Chem Biol, 2013. 9(4): p. 247-9.
78. Deirdre Jill, C., et al., Vismodegib (V), a hedgehog (HH) pathway inhibitor, combined with FOLFOX for first-line therapy of patients (pts) with advanced gastric and gastroesophageal junction (GEJ) carcinoma: A New York Cancer Consortium led phase II randomized study. Journal of Clinical Oncology, 2013. 31(15_suppl): p. 4011-4011.
79. Yoon, C., et al., CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance. Clin Cancer Res, 2014. 20(15): p. 3974-88.
80. Merchant, J.L. and L. Ding, Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor Lesions. Cellular and Molecular Gastroenterology and Hepatology, 2017. 3(2): p. 201-210.
81. Cancer Genome Atlas Research, N., Comprehensive molecular characterization of gastric adenocarcinoma. Nature, 2014. 513(7517): p. 202-9.
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