Page 101 - The role of advanced echocardiography in patients with ischemic heart disease - Rachid Abou

The incremental value of LV layer-specific GLS analysis. A baseline model consisting of BSA, heart rate at discharge, diabetes mellitus, peak troponin level, LVEF, WMSI, significant MR, LAD as culprit vessel and Killip class ≥2 was constructed (Table 5). To determine the incremental value of layer-specific LV GLS on clinical and conventional echocardiographic parameters, global χ2 values were calculated using logistic regression models. For all models, adverse LV remodeling was considered as the primary outcome. The correlation coefficient for layer-specific LV GLS was >0.7 (endocardial vs. mid-myocardium; r=0.986, p<0.001), (endocardial vs. epicardium; r=0.923, p<0.001) and (mid-myocardium vs. epicardium; r=0.974, p<0.001). Therefore, these variables could not be introduced into the same multivariate model and were introduced individually to the baseline model to avoid multi-collinearity. The addition layer-specific of LV GLS to the baseline model resulted in a significant increase in χ2 values, which was highest for LV epicardial GLS (Figure 3).
Figure 3. The incremental value of layer-specific left ventricular global longitudinal strain over baseline clinical and echocardiographic variables associated with adverse left ventricular remodeling.
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